L-PRF for biomimetics
Introduction
Biomimicry refers to a process whereby the deposition of the host's own proteins and extracellular matrix enhances the biocompatibility of an implant and, thereby accelerating the osteogenic healing process.
The available evidence suggests that the clinical benefits of the liquid form of L-PRF (liquid fibrinogen) on any implant surface appear to be limited.
However, the application of L-PRF membranes into the osteotomy site may provide positive clinical effects during the early stages of healing (up to 6 weeks) by promoting early implant stability, particularly in low-density bone, and by reducing the initial marginal bone loss (Ivanovski et al. 2025).
Different options for biomimicry
irrigation
dipping
wrap
inserting into the socket
Interaction between implant surface and liquid fibrinogen
In vitro studies indicated that the biomimicry effect depends on the implant surface, as illustrated by this image. For more details see Andrade et al. 2021.
Data:
RCTs/CCTs illustrating the impact of "biomimicry" with L-PRF
Abbreviations: Subjects: n = number, ♀ = female, ♂ = male; Groups: different applications, cover bone = covering bone around implant, ins = inserted in osteotomy before implant insertion, ex = exudate, dip = dipping implant into L-PRF exudate, irr = irrigating/humidifying implant surface, C = control group, T = test group, (..) = number of patients/sites, L-PRF = leukocyte- and platelet-rich fibrin (acronym as mentioned in the paper: CGF = concentrated growth factor), m = membrane; different outcome variables, MBL = marginal bone level, PPD = probing pocket depth, ISQ = implant stability quotient (Ostell).
Conclusion
Eleven randomized controlled trials (RCTs) / controlled clinical trials (CCTs) presented data on the use of L-PRF to enhance the implant surface, with 8 studies focusing on implants placed in healed sites and 3 on immediate implant placement in fresh extraction sites.
For healed sites, the insertion of an L-PRF membrane into the osteotomy site almost always resulted in higher implant stability quotient (ISQ) values compared to control sites without L-PRF, particularly during the first 4 to 6 weeks. This effect was most pronounced at sites with low bone quality/density (e.g., implants with low initial ISQ values). The application of L-PRF liquid (exudate or liquid fibrinogen) alone had a negligible impact.
For immediate implant placement, the application of L-PRF in the jumping gap did not consistently improve outcomes. One study reported positive results, while 2 other studies found no significant difference compared to non-treated implants (for more information, see Ivanokski et al. 2025).
Important notice
Clinical experience:
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Liquid L-PRF does not seem to offer any benefit, but the application of an L-PRF membrane in the osteotomy before implant insertion, will enhance the osseointegration process, especially in areas with low bone density.
Interesting references
Several videos and/or cases on this webpage are discussed more in detail in the following book: Quirynen M & Pinto N 2022. Leukocyte- and Platelet-Rich Fibrin in Oral Regenerative Procedures. Quintessence Publishing; ISBN: 978-1-78698-105-9